5-[4-(4-(2-AMINO-2 METHOXYCARBONYLETHYL)PHENOXY)BENZILIDENE]THIAZOLIDIN-2,4-DIONE DERIVATIVES AND RELATED COMPOUNDS FOR REDUCING GLUCOSE, CHOLESTEROL AND TRIGLYCERIDE LEVELS IN PLASMA
Diphenyl ether compounds of the formula (I) are provided th-it exhibit activity useful for reducing glucose, cholesterol, and/or triglyceride levels in plasma, and for treatment of obesity, inflammation, immunological diseases, autoimmune diseases, diabetes and disorders associated with insulin resi...
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| creator | AGARWAL, SHIV KUMAR BADIGER, SANGAMESH NAG, ABHIJEET NEOGI, PARTHA NAG, BISHWAJIT DEY, DEBENDRANATH REDDY, GADDAM OM PANDEY, SURENDRA KUMAR SINGH, GAJENDRA CHITHRA, SANTHANAGOPALAN |
| description | Diphenyl ether compounds of the formula (I) are provided th-it exhibit activity useful for reducing glucose, cholesterol, and/or triglyceride levels in plasma, and for treatment of obesity, inflammation, immunological diseases, autoimmune diseases, diabetes and disorders associated with insulin resistance. (I) wherein represents an optional bond; W represents O or S; Z represents CR10, O or S; G represents O, S or together with R10 forms a 5 or 6 membered aromatic or heteroaromatic ring system containing 1 or 2 heteroatoms selected from the group consisting of O, S and N; R8 represents OR13 or NR14R15; where R13 is selected from the group consisting of hydrogen, substituted and unsubstituted (C1-C20) alkyl, (C2-C20) alkenyl, (C5-C14) aryl, (C6-C34) aralkyl, (C1C13) heteroaryl, and a counter ion; and where R14 and R15 are independently selected from the group consisting of H, substituted and unsubstituted (C1-C20) alkyl, (C2-C20) alkenyl and (C5-C14) aryl; the other substituents are defined in the claims. |
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(I) wherein represents an optional bond; W represents O or S; Z represents CR10, O or S; G represents O, S or together with R10 forms a 5 or 6 membered aromatic or heteroaromatic ring system containing 1 or 2 heteroatoms selected from the group consisting of O, S and N; R8 represents OR13 or NR14R15; where R13 is selected from the group consisting of hydrogen, substituted and unsubstituted (C1-C20) alkyl, (C2-C20) alkenyl, (C5-C14) aryl, (C6-C34) aralkyl, (C1C13) heteroaryl, and a counter ion; and where R14 and R15 are independently selected from the group consisting of H, substituted and unsubstituted (C1-C20) alkyl, (C2-C20) alkenyl and (C5-C14) aryl; the other substituents are defined in the claims.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2014</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20140527&DB=EPODOC&CC=CA&NR=2598087C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20140527&DB=EPODOC&CC=CA&NR=2598087C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>AGARWAL, SHIV KUMAR</creatorcontrib><creatorcontrib>BADIGER, SANGAMESH</creatorcontrib><creatorcontrib>NAG, ABHIJEET</creatorcontrib><creatorcontrib>NEOGI, PARTHA</creatorcontrib><creatorcontrib>NAG, BISHWAJIT</creatorcontrib><creatorcontrib>DEY, DEBENDRANATH</creatorcontrib><creatorcontrib>REDDY, GADDAM OM</creatorcontrib><creatorcontrib>PANDEY, SURENDRA KUMAR</creatorcontrib><creatorcontrib>SINGH, GAJENDRA</creatorcontrib><creatorcontrib>CHITHRA, SANTHANAGOPALAN</creatorcontrib><title>5-[4-(4-(2-AMINO-2 METHOXYCARBONYLETHYL)PHENOXY)BENZILIDENE]THIAZOLIDIN-2,4-DIONE DERIVATIVES AND RELATED COMPOUNDS FOR REDUCING GLUCOSE, CHOLESTEROL AND TRIGLYCERIDE LEVELS IN PLASMA</title><description>Diphenyl ether compounds of the formula (I) are provided th-it exhibit activity useful for reducing glucose, cholesterol, and/or triglyceride levels in plasma, and for treatment of obesity, inflammation, immunological diseases, autoimmune diseases, diabetes and disorders associated with insulin resistance. (I) wherein represents an optional bond; W represents O or S; Z represents CR10, O or S; G represents O, S or together with R10 forms a 5 or 6 membered aromatic or heteroaromatic ring system containing 1 or 2 heteroatoms selected from the group consisting of O, S and N; R8 represents OR13 or NR14R15; where R13 is selected from the group consisting of hydrogen, substituted and unsubstituted (C1-C20) alkyl, (C2-C20) alkenyl, (C5-C14) aryl, (C6-C34) aralkyl, (C1C13) heteroaryl, and a counter ion; and where R14 and R15 are independently selected from the group consisting of H, substituted and unsubstituted (C1-C20) alkyl, (C2-C20) alkenyl and (C5-C14) aryl; the other substituents are defined in the claims.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2014</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFjMFKA0EQRPfiQdRvsI8GMiBrQpLjZKaz29DbvczMLtmIhCDjSTQQ_83fcxDvQkFRj6q6rr6X5nlhHopqYzsSNTV0mFrdT86GrcrEJU0861uUAmdblAMxeRR8SS3Zg5ZAYur5wnhSQfAYaLSJRoxgxUNAtgk9OO16HcRH2Gko1A-OpIGGB6cR5-BaZYwJg_LvLgVqeHLlzSMwjsgRSKBnGzt7W129nd4v-e7Pb6r7HSbXmnz-PObL-fSaP_LX0dl6uVk_rlfu6f_GD43mSkQ</recordid><startdate>20140527</startdate><enddate>20140527</enddate><creator>AGARWAL, SHIV KUMAR</creator><creator>BADIGER, SANGAMESH</creator><creator>NAG, ABHIJEET</creator><creator>NEOGI, PARTHA</creator><creator>NAG, BISHWAJIT</creator><creator>DEY, DEBENDRANATH</creator><creator>REDDY, GADDAM OM</creator><creator>PANDEY, SURENDRA KUMAR</creator><creator>SINGH, GAJENDRA</creator><creator>CHITHRA, SANTHANAGOPALAN</creator><scope>EVB</scope></search><sort><creationdate>20140527</creationdate><title>5-[4-(4-(2-AMINO-2 METHOXYCARBONYLETHYL)PHENOXY)BENZILIDENE]THIAZOLIDIN-2,4-DIONE DERIVATIVES AND RELATED COMPOUNDS FOR REDUCING GLUCOSE, CHOLESTEROL AND TRIGLYCERIDE LEVELS IN PLASMA</title><author>AGARWAL, SHIV KUMAR ; BADIGER, SANGAMESH ; NAG, ABHIJEET ; NEOGI, PARTHA ; NAG, BISHWAJIT ; DEY, DEBENDRANATH ; REDDY, GADDAM OM ; PANDEY, SURENDRA KUMAR ; SINGH, GAJENDRA ; CHITHRA, SANTHANAGOPALAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2598087C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2014</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>AGARWAL, SHIV KUMAR</creatorcontrib><creatorcontrib>BADIGER, SANGAMESH</creatorcontrib><creatorcontrib>NAG, ABHIJEET</creatorcontrib><creatorcontrib>NEOGI, PARTHA</creatorcontrib><creatorcontrib>NAG, BISHWAJIT</creatorcontrib><creatorcontrib>DEY, DEBENDRANATH</creatorcontrib><creatorcontrib>REDDY, GADDAM OM</creatorcontrib><creatorcontrib>PANDEY, SURENDRA KUMAR</creatorcontrib><creatorcontrib>SINGH, GAJENDRA</creatorcontrib><creatorcontrib>CHITHRA, SANTHANAGOPALAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>AGARWAL, SHIV KUMAR</au><au>BADIGER, SANGAMESH</au><au>NAG, ABHIJEET</au><au>NEOGI, PARTHA</au><au>NAG, BISHWAJIT</au><au>DEY, DEBENDRANATH</au><au>REDDY, GADDAM OM</au><au>PANDEY, SURENDRA KUMAR</au><au>SINGH, GAJENDRA</au><au>CHITHRA, SANTHANAGOPALAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>5-[4-(4-(2-AMINO-2 METHOXYCARBONYLETHYL)PHENOXY)BENZILIDENE]THIAZOLIDIN-2,4-DIONE DERIVATIVES AND RELATED COMPOUNDS FOR REDUCING GLUCOSE, CHOLESTEROL AND TRIGLYCERIDE LEVELS IN PLASMA</title><date>2014-05-27</date><risdate>2014</risdate><abstract>Diphenyl ether compounds of the formula (I) are provided th-it exhibit activity useful for reducing glucose, cholesterol, and/or triglyceride levels in plasma, and for treatment of obesity, inflammation, immunological diseases, autoimmune diseases, diabetes and disorders associated with insulin resistance. (I) wherein represents an optional bond; W represents O or S; Z represents CR10, O or S; G represents O, S or together with R10 forms a 5 or 6 membered aromatic or heteroaromatic ring system containing 1 or 2 heteroatoms selected from the group consisting of O, S and N; R8 represents OR13 or NR14R15; where R13 is selected from the group consisting of hydrogen, substituted and unsubstituted (C1-C20) alkyl, (C2-C20) alkenyl, (C5-C14) aryl, (C6-C34) aralkyl, (C1C13) heteroaryl, and a counter ion; and where R14 and R15 are independently selected from the group consisting of H, substituted and unsubstituted (C1-C20) alkyl, (C2-C20) alkenyl and (C5-C14) aryl; the other substituents are defined in the claims.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 5-[4-(4-(2-AMINO-2 METHOXYCARBONYLETHYL)PHENOXY)BENZILIDENE]THIAZOLIDIN-2,4-DIONE DERIVATIVES AND RELATED COMPOUNDS FOR REDUCING GLUCOSE, CHOLESTEROL AND TRIGLYCERIDE LEVELS IN PLASMA |
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