5-[4-(4-(2-AMINO-2 METHOXYCARBONYLETHYL)PHENOXY)BENZILIDENE]THIAZOLIDIN-2,4-DIONE DERIVATIVES AND RELATED COMPOUNDS FOR REDUCING GLUCOSE, CHOLESTEROL AND TRIGLYCERIDE LEVELS IN PLASMA
Diphenyl ether compounds of the formula (I) are provided th-it exhibit activity useful for reducing glucose, cholesterol, and/or triglyceride levels in plasma, and for treatment of obesity, inflammation, immunological diseases, autoimmune diseases, diabetes and disorders associated with insulin resi...
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Zusammenfassung: | Diphenyl ether compounds of the formula (I) are provided th-it exhibit activity useful for reducing glucose, cholesterol, and/or triglyceride levels in plasma, and for treatment of obesity, inflammation, immunological diseases, autoimmune diseases, diabetes and disorders associated with insulin resistance. (I) wherein represents an optional bond; W represents O or S; Z represents CR10, O or S; G represents O, S or together with R10 forms a 5 or 6 membered aromatic or heteroaromatic ring system containing 1 or 2 heteroatoms selected from the group consisting of O, S and N; R8 represents OR13 or NR14R15; where R13 is selected from the group consisting of hydrogen, substituted and unsubstituted (C1-C20) alkyl, (C2-C20) alkenyl, (C5-C14) aryl, (C6-C34) aralkyl, (C1C13) heteroaryl, and a counter ion; and where R14 and R15 are independently selected from the group consisting of H, substituted and unsubstituted (C1-C20) alkyl, (C2-C20) alkenyl and (C5-C14) aryl; the other substituents are defined in the claims. |
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