EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGS

This application discloses a process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following. (see abov...

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Hauptverfasser:	SUDHAKAR, ANANTHA, SABESAN, VIJAY, WU, GEORGE G, CUI, JIAN, THIRUVENGADAM, TIRUVETTIPURAM K, WANG, TAO, HUANG, MINGSHENG, ZAVIALOV, ILIA, CHEN, FRANK XING, YANG, XIAOJING, NGUYEN, HOA N, XIE, JI, LIM, NGIAP KIE, LIAO, JING, POIRIER, MARC, KWOK, DAW-LONG
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	This application discloses a process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following. (see above formula) L'invention concerne un procédé de préparation d'analogues de l'himbacine utiles comme antagonistes des récepteurs de la thrombine. Le procédé est fondé partiellement sur l'utilisation d'une épimérisation dynamique à promotion basique d'un centre nitro chiral. La chimie définie dans la description peut être exemplifiée par celui-ci.