PURIFIED RHIGF-I/RHIGFBP-3 COMPLEXES AND THEIR METHOD OF MANUFACTURE

Complexes of IGF-I and IGFBP-3 with new levels of purity are provided. Chromatographic techniques have been developed that remove contaminants, such as mass and charge variants of IGFBP-3. The new techniques enable the production of high-quality pharmaceutical compositions comprising IGF-I/IGFBP-3 c...

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Hauptverfasser:	SLEEVI, MARK C, KELLEY, GLEN L
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:	Complexes of IGF-I and IGFBP-3 with new levels of purity are provided. Chromatographic techniques have been developed that remove contaminants, such as mass and charge variants of IGFBP-3. The new techniques enable the production of high-quality pharmaceutical compositions comprising IGF-I/IGFBP-3 complexes. La présente invention concerne des complexes de IGF-I et IGFBP-3 de trois nouveaux niveaux de pureté. L'invention concerne également des techniques chromatographiques d'élimination de contaminants tels que les variantes masse et charge d'IGFBP-3. Ces nouvelles techniques permettent la production de compositions pharmaceutiques de haute qualité comprenant des complexes IGF-I/IGFBP-3.