DEACYLATION OF LPS IN GRAM NEGATIVE BACTERIA

The current invention provides new Gram negative polypeptides exhibiting lipid A 3-O-deacylase activity and are capable of modifying and/or detoxifying gram negative LPS. The present invention also provides Gram negative bacteria, Gram negative bacterial lipopolysaccharides (LPS) and compositions co...

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Bibliographische Detailangaben
Hauptverfasser:	GEURTSEN, JEROEN JOHANNES GERARDUS, TOMMASSEN, JOHANNES PETRUS MARIA, VAN DER LEY, PETER ANDRE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The current invention provides new Gram negative polypeptides exhibiting lipid A 3-O-deacylase activity and are capable of modifying and/or detoxifying gram negative LPS. The present invention also provides Gram negative bacteria, Gram negative bacterial lipopolysaccharides (LPS) and compositions comprising LPS, which are provided with or treated with a 3-O-deacylase activity according to the invention and which may be used for pharmaceutical and/or veterinary purposes, in particular for the preparation of whole cell or acellular vaccines against pathogenic Gram negatives such as Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica. L'invention concerne de nouveaux polypeptides Gram-négatifs présentant une activité 3-O-déacylase de lipide A et capables de modifier et/ou de détoxifier des lipopolysaccharides bactériens Gram-négatifs (LPS). L'invention concerne également des bactéries Gram-négatives, des LPS Gram-négatifs et des compositions comprenant lesdits LPS qui présentent une activité 3-O-déacylase ou sont traités par celle-ci, et qui peuvent être utilisés à des fins pharmaceutiques et/ou vétérinaires, en particulier, pour des vaccins à cellules entières ou acellulaires contre des pathogènes Gram-négatifs, tels que Bordetella pertussis, Bordetella parapertussis et Bordetella bronchiseptica.