RECOMBINANT BCG STRAINS WITH ENHANCED ABILITY TO ESCAPE THE ENDOSOME

Mycobacterium strains that have an enhanced ability to elicit a Histocompatibility-Class I-restricted CD8+ T cell immune response are provided. The Mycobacterium strains are genetically engineered to express an endosomalytic protein that is active at neutral pH (e.g. Perfringolysin O), permitting es...

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Bibliographische Detailangaben
Hauptverfasser:	HONE, DAVID MICHAEL, SADOFF, JERALD C, SUN, RONGGAI
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Mycobacterium strains that have an enhanced ability to elicit a Histocompatibility-Class I-restricted CD8+ T cell immune response are provided. The Mycobacterium strains are genetically engineered to express an endosomalytic protein that is active at neutral pH (e.g. Perfringolysin O), permitting escape of the Mycobacterium from endosomes into the cytoplasm of the cell. The invention also provides vaccine preparations containing the Mycobacterium strains. L'invention concerne des souches de Mycobacterium capables de déclencher une réaction immunitaire à lymphocytes T CD8+ restreints par le complexe majeur d'histocompatibilité de classe 1. Ces souches de Mycobacterium sont modifiées génétiquement pour exprimer une protéine de l'endosome active à un pH neutre (telle que la perfringolysine O, par exemple), afin de permettre à Mycobacterium de s'échapper des endosomes dans le cytoplasme de la cellule. L'invention concerne également des préparations vaccinales contenant ces souches de Mycobacterium.