CYCLIC AMINE DERIVATIVE OR SALT THEREOF

Provided are compounds which are an NMDA antagonist having a broad safety margin and are useful as a treating agent or a preventing agent for Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, ischemic apoplexy, pain, etc. Concretely provided are an amine derivative or its...

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Bibliographische Detailangaben
Hauptverfasser:	YAMASAKI, SHINGO, SUZUKI, DAISUKE, KANAYAMA, TAKATOSHI, TOBE, TAKAHIKO, MAENO, KYOICHI, HAYASHIBE, SATOSHI, KAWABATA, SHIGEKI, OHMORI, JUNYA, SUZUKI, JOTAROU, SHIRAISHI, NOBUYUKI, HOSHII, HIROAKI, SHITAKA, YOSHITSUGU
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY METALLURGY ORGANIC CHEMISTRY
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	Provided are compounds which are an NMDA antagonist having a broad safety margin and are useful as a treating agent or a preventing agent for Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, ischemic apoplexy, pain, etc. Concretely provided are an amine derivative or its salt characterized in that the amine-containing structure A therein bonds to a 2- or 3-cyclic condensed ring (e.g., indane, tetralone,4,5,6,7--tetrahydrobenzothiophene, 4,5,6,7-tetrahydrobenzofuran, 7,8-dihydro-6H-indeno[4,5--b]furan,2,3-dihydro-1H-cyclopenta[1]naphthalene) via X1(bond or lower alkylene); and an NMDA antagonist containing it as an active ingredient thereof.