STEREOISOMERICALLY ENRICHED .BETA.-LACTAMS USING CANDIDA ANTARCTICA

STEREOISOMERICALLY ENRICHED .BETA.-LACTAMS USING CANDIDA ANTARCTICA

The present disclosure provides enzymatic methods for generating stereoisomerically pure products by resolving a racemic mixture of N-protected .beta.-lactams with a lipase from Candida antarcticawith high stereospecificity. The presence of a carbamate protecting group, such as the tert-butoxycarbon...

Ausführliche Beschreibung

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Bibliographische Detailangaben
1. Verfasser: ARGADE, ANKUSH
Format: Patent
Sprache:eng ; fre
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The present disclosure provides enzymatic methods for generating stereoisomerically pure products by resolving a racemic mixture of N-protected .beta.-lactams with a lipase from Candida antarcticawith high stereospecificity. The presence of a carbamate protecting group, such as the tert-butoxycarbonyl group protecting group, on the (3-lactam enhances enzyme catalysis and stereoselectivity. La présente invention concerne des procédés enzymatiques permettant de générer des produits stéréoïsomériquement purs par résolution d'un mélange racémique de ß-lactams N-protégés avec une lipase issue de Candida antarctica de haute stéréospécificité. La présence d'un groupe protecteur carbamate, et notamment tert-butoxycarbonyle, sur le ß-lactam renforce la catalyse et la stéréosélectivité des enzymes.