PULMONARY DELIVERY OF A NERVE AGENT NEUTRALIZING ENZYME

The present invention provides for non-invasive treatment of nerve agent poisoning by administering nerve agent neutralizing enzymes to the pulmonary epithelium of a subject, by inhalation, where they accumulate within the lungs. Localization of such enzymes in the pulmonary epithelium results in neutralization of the nerve agents at the lungs. As a result, nerve agents move by diffusion out of the blood through the pulmonary capillaries, duc to the organophosphorus nerve agents rapid diffusion across the cell membranes of the body via diffusion, down their concentration gradients. The present invention presents a practical method of administering nerve agent neutralizing enzymes, without requiring passage into the blood plasma, and without requiring blood plasma activity of the enzyme.