NOVEL CRYSTALLINE FORMS OF 6ALPHA, 9ALPHA-DIFLUORO-11BETA HYDROXY-16ALPHA-METHYL-3-OXO-17ALPHA-PROPIONYLOXY-ANDROSTA-1,4-DIENE-17BETA-CARBOXYLIC ACID AND PROCESSES FOR PREPARATIONTHEREOF

NOVEL CRYSTALLINE FORMS OF 6ALPHA, 9ALPHA-DIFLUORO-11BETA HYDROXY-16ALPHA-METHYL-3-OXO-17ALPHA-PROPIONYLOXY-ANDROSTA-1,4-DIENE-17BETA-CARBOXYLIC ACID AND PROCESSES FOR PREPARATIONTHEREOF

Novel crystalline forms II, III, IV, V, VI, VII and VIII of 6alpha,9alpha-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-propionyloxyandrosta-1,4-diene-17beta-carboxylic acid, a chemical intermediate useful in the preparation of fluticasone propionate, and novel methods of making these forms,...

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Bibliographische Detailangaben
Hauptverfasser: FUTERMAN, YURI, IUSTAIN, CARMEN, ADIN, ITAI
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Novel crystalline forms II, III, IV, V, VI, VII and VIII of 6alpha,9alpha-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-propionyloxyandrosta-1,4-diene-17beta-carboxylic acid, a chemical intermediate useful in the preparation of fluticasone propionate, and novel methods of making these forms, substantially free of water, are disclosed.