PROCESS FOR PREPARING ACYCLIC HCV PROTEASE INHIBITORS

Disclosed are highly convergent processes for preparing compounds of formula (I), which compounds are potent active agents for the treatment of hepatitis C virus (HCV) infection. The disclosed processes use SNAr-type coupling reactions between peptidic compounds having a hydroxyproline moiety and ha...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	SENANAYAKE, CHRIS HUGH, HADDAD, NIZAR, KAPADIA, SURESH R, FRUTOS, ROGELIO PEREZ, LORENZ, JON CHARLES, BUSACCA, CARL ALAN, WEI, XUDONG, SAHA, ANJAN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Disclosed are highly convergent processes for preparing compounds of formula (I), which compounds are potent active agents for the treatment of hepatitis C virus (HCV) infection. The disclosed processes use SNAr-type coupling reactions between peptidic compounds having a hydroxyproline moiety and halogenated or sulfonated bromoquinoline compounds. La présente invention concerne des processus hautement convergents de préparation de composés représentés par la formule (I), ces composés étant des agents actifs puissants destinés au traitement d'une infection par le virus de l'hépatite C (VHC). Des processus de cette invention utilisent des réactions de couplage de type SNAr entre des composés peptidiques possédant une fraction hydroxyproline et des composés bromoquinoline halogénés ou sulfonés.