PREPARATION OF CABERGOLINE FORM I FROM A SOLVATE OF CABERGOLINE AND ETHYLBENZENE

PREPARATION OF CABERGOLINE FORM I FROM A SOLVATE OF CABERGOLINE AND ETHYLBENZENE

The present invention discloses a method for preparing cabergoline form I by combining cabergoline and a solvent comprising ethylbenzene to form a solvate and obtaining form I from the solvate. Also disclosed is a method for preparing cabergoline form I by combining cabergoline and a fist solvent to...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: GREENWOOD, ALAN KENNETH, BHATARAH, PARVEEN, MCHATTIE, DEREK, GAMBLE, MARK
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The present invention discloses a method for preparing cabergoline form I by combining cabergoline and a solvent comprising ethylbenzene to form a solvate and obtaining form I from the solvate. Also disclosed is a method for preparing cabergoline form I by combining cabergoline and a fist solvent to form a solution and additionally including a second solvent to the solution, followed by crystallisation to form cabergoline form I. Further disclosed is a solvate form of cabergoline comprising cabergoline and ethylbenzene and, optionally, n-heptane. (see formula I)