MICROFLUIDIZED OIL-IN-WATER EMULSIONS AND VACCINE COMPOSITIONS

This invention provides submicron oil-in water emulsions useful as a vaccine adjuvant for enhancing the immunogenicity of antigens. The present invention also provides vaccine compositions containing an antigen combined with such emulsions intrinsically or extrinsically. Methods of preparing the emu...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	DOMINOWSKI, PAUL JOSEPH, MANNAN, RAMASAMY MANNAR, KREBS, RICHARD LEE, KLOSE, PAMELA KAY
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	This invention provides submicron oil-in water emulsions useful as a vaccine adjuvant for enhancing the immunogenicity of antigens. The present invention also provides vaccine compositions containing an antigen combined with such emulsions intrinsically or extrinsically. Methods of preparing the emulsions and vaccines are also provided by the present invention. L'invention concerne des émulsions huile dans eau submicroniques, utiles comme adjuvants de vaccin pour améliorer le caractère immunogène des antigènes. L'invention concerne également des compositions de vaccin qui renferment un antigène combiné avec ces émulsions, de façon intrinsèque ou extrinsèque, et des procédés d'élaboration pour les émulsions et les vaccins.