IMPROVED PROCESS FOR THE PREPARATION OF 9,11 EPOXY STEROIDS

IMPROVED PROCESS FOR THE PREPARATION OF 9,11 EPOXY STEROIDS

Processes are described for epoxidation reactions. In particular, the proces s comprises the conversion of a steroid substrate having an olefinic unsaturation in the steroid nucleus to a structure comprising a 9,11-epoxy substituent by reaction of the substrate with a peroxide compound in the presen...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: DAVID, PAUL, MAISTO, KEITH D, WIECZOREK, JOSEPH J, KIM, CHUNG C, CARLOS, MARLON V
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Beschreibung
Zusammenfassung:Processes are described for epoxidation reactions. In particular, the proces s comprises the conversion of a steroid substrate having an olefinic unsaturation in the steroid nucleus to a structure comprising a 9,11-epoxy substituent by reaction of the substrate with a peroxide compound in the presence of a peroxide activator. The epoxidation processes described are conducted at relatively low hydrogen peroxide to steroid substrate ratio. Several optional process modifications are described.