HETEROARYL PIPERIDINE GLYCINE TRANSPORTER INHIBITORS

The present invention is directed to pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl piperidine compounds that inhibit the glycine transporter GlyT1 an d which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutamatergic neurotransmission dysfunc...

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Bibliographische Detailangaben
Hauptverfasser:	WOLKENBERG, SCOTT E, HARTMAN, GEORGE D, WANG, YI, HALLETT, DAVID, BLACKABY, WESLEY, LEWIS, RICHARD T, NAYLOR, ELIZABETH, JENNINGS, ANDREW S, LEISTER, WILLIAM H, DUGGAN, MARK E, LINDSLEY, CRAIG W, WISNOSKI, DAVID D, STREET, LESLIE J, ZHAO, ZHIJIAN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention is directed to pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl piperidine compounds that inhibit the glycine transporter GlyT1 an d which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutamatergic neurotransmission dysfunction a nd diseases in which the glycine transporter GlyT1 is involved.