THROMBIN DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

It is intended to provide a thrombin derivative comprising A and B chains wherein the B chain has an amino acid sequence derived from the amino acid sequence of thrombin B chain by the substitution at one or more active cente r amino acids selected from among serine at the 205-position, glycine at t...

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Bibliographische Detailangaben
Hauptverfasser:	HOSOKAWA, KAZUYA, KASHIMA, KOSUKE
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	It is intended to provide a thrombin derivative comprising A and B chains wherein the B chain has an amino acid sequence derived from the amino acid sequence of thrombin B chain by the substitution at one or more active cente r amino acids selected from among serine at the 205-position, glycine at the 2 03- position, aspartic acid at the 99-position and histidine at the 43-position, and (1) in the case of reacting with a thrombin substrate at 37oC for 3 hour s in a 50 mM tris hydrochloride buffer (pH 7.4) containing 0.1 M of NaCl, the ratio of the thrombin substrate decomposed by the thrombin derivative being 10% or lower; and (2) sustaining the structure of exocite I.