POLYMORPHIC AND AMORPHOUS FORMS OF 2,5-DIMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID {2-FLUORO-5-[3-((E)-2-PYRIDIN-2-YL-VINYL)-1H-INDASOL-6-YLAMINO]-PHENYL}-AMIDE

POLYMORPHIC AND AMORPHOUS FORMS OF 2,5-DIMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID {2-FLUORO-5-[3-((E)-2-PYRIDIN-2-YL-VINYL)-1H-INDASOL-6-YLAMINO]-PHENYL}-AMIDE

The invention provides several polymorphic forms and an amorphous form of 2,5-Dimethyl-2H-pyrazole-3-carboxylic acid {2-fluoro-5-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-ylamino]-phenyl}-amide, pharmaceutical compositions containing such polymorphic or amorphous forms, and methods of using such ph...

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Hauptverfasser: OUELLETTE, MICHAEL ALLEN, KANIA, ROBERT STEVEN, SRIRANGAM, JAYARAM KASTURI, WIGHTLIN, MATTHEW DAVID, MITCHELL, MARK BRYAN, SAEED, NABIL LAUZE, HETTINGER, DONALD NICHOLAS, ZOOK, SCOTT EDWARD, YE, QIANG
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:The invention provides several polymorphic forms and an amorphous form of 2,5-Dimethyl-2H-pyrazole-3-carboxylic acid {2-fluoro-5-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-ylamino]-phenyl}-amide, pharmaceutical compositions containing such polymorphic or amorphous forms, and methods of using such pharmaceutical compositions to treat disease states mediated by protein kinases, such as cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation.