A SUBSTITUTED-TRIALKYL AMINE COMPOUND WITH ANTI-VIRAL ACTIVITY BASED ON ANTAGONISM AGAINST A CHEMOKINE RECEPTOR CXCR4
Novel amine compounds which are represented by the following formula (1) and efficacious against diseases such as a viral infectious disease with HIV, rheumatism, and cancer metastasis; [Formula 1] (see formula 1) typically, A1 and A2 represent a hydrogen atom or a substitutable monocyclic or polycy...
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| creator | SAITOU, ATSUSHI SUZUKI, SHIGERU KIKUMOTO, SHIGEYUKI YANAKA, MIKIRO ONO, MASAHIRO MATSUI, RYO YAMAMOTO, MASASHI SAWA, TOMOHIRO |
| description | Novel amine compounds which are represented by the following formula (1) and efficacious against diseases such as a viral infectious disease with HIV, rheumatism, and cancer metastasis; [Formula 1] (see formula 1) typically, A1 and A2 represent a hydrogen atom or a substitutable monocyclic or polycyclic heteroaromatic ring and W represents a substitutable benzene ring or any group represented by the following formula (10) or (11): [Formula 2] (see formula 10) [Formula 3] (see formula 11) where X represents O, CH2, C (=O) , NR11, or CHR35 and D represents a group represented by the following formula (6) : [Formula 4] (see formula 6) where Q represents a single bond, NR12, or a group represented by the formula (13) : [Formula 5] (see formula 13) and Y represents a group represented by the following formula (7): [Formula 6] (see formula 7) where Q represents a substitutable monocyclic or polycyclic aromatic ring; and B represents -NR25R26; and R1 to R26 in the above formulae represent a hydrogen atom, an alkyl group, an alkenyl group, or an alkynyl group. |
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SUZUKI, SHIGERU ; KIKUMOTO, SHIGEYUKI ; YANAKA, MIKIRO ; ONO, MASAHIRO ; MATSUI, RYO ; YAMAMOTO, MASASHI ; SAWA, TOMOHIRO</creatorcontrib><description>Novel amine compounds which are represented by the following formula (1) and efficacious against diseases such as a viral infectious disease with HIV, rheumatism, and cancer metastasis; [Formula 1] (see formula 1) typically, A1 and A2 represent a hydrogen atom or a substitutable monocyclic or polycyclic heteroaromatic ring and W represents a substitutable benzene ring or any group represented by the following formula (10) or (11): [Formula 2] (see formula 10) [Formula 3] (see formula 11) where X represents O, CH2, C (=O) , NR11, or CHR35 and D represents a group represented by the following formula (6) : [Formula 4] (see formula 6) where Q represents a single bond, NR12, or a group represented by the formula (13) : [Formula 5] (see formula 13) and Y represents a group represented by the following formula (7): [Formula 6] (see formula 7) where Q represents a substitutable monocyclic or polycyclic aromatic ring; and B represents -NR25R26; and R1 to R26 in the above formulae represent a hydrogen atom, an alkyl group, an alkenyl group, or an alkynyl group.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2013</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130709&DB=EPODOC&CC=CA&NR=2558600C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130709&DB=EPODOC&CC=CA&NR=2558600C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SAITOU, ATSUSHI</creatorcontrib><creatorcontrib>SUZUKI, SHIGERU</creatorcontrib><creatorcontrib>KIKUMOTO, SHIGEYUKI</creatorcontrib><creatorcontrib>YANAKA, MIKIRO</creatorcontrib><creatorcontrib>ONO, MASAHIRO</creatorcontrib><creatorcontrib>MATSUI, RYO</creatorcontrib><creatorcontrib>YAMAMOTO, MASASHI</creatorcontrib><creatorcontrib>SAWA, TOMOHIRO</creatorcontrib><title>A SUBSTITUTED-TRIALKYL AMINE COMPOUND WITH ANTI-VIRAL ACTIVITY BASED ON ANTAGONISM AGAINST A CHEMOKINE RECEPTOR CXCR4</title><description>Novel amine compounds which are represented by the following formula (1) and efficacious against diseases such as a viral infectious disease with HIV, rheumatism, and cancer metastasis; [Formula 1] (see formula 1) typically, A1 and A2 represent a hydrogen atom or a substitutable monocyclic or polycyclic heteroaromatic ring and W represents a substitutable benzene ring or any group represented by the following formula (10) or (11): [Formula 2] (see formula 10) [Formula 3] (see formula 11) where X represents O, CH2, C (=O) , NR11, or CHR35 and D represents a group represented by the following formula (6) : [Formula 4] (see formula 6) where Q represents a single bond, NR12, or a group represented by the formula (13) : [Formula 5] (see formula 13) and Y represents a group represented by the following formula (7): [Formula 6] (see formula 7) where Q represents a substitutable monocyclic or polycyclic aromatic ring; and B represents -NR25R26; and R1 to R26 in the above formulae represent a hydrogen atom, an alkyl group, an alkenyl group, or an alkynyl group.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2013</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFjMEKgkAQQL10iOobmh8QpDK6juOmg7obu6PlSSS2U5Rg_X8J3Tu9w3u8efBGcHXihKUWlYZiGcuiLQEr1grIVCdT6xTOLDmgFg4btvjVJNywtJCgUykYPUnMjGZXAWbI2gkgUK4qU0wnq0idxFigC9ndMpjd-vvoVz8ugvVRCeWhH56dH4f-6h_-1RFu4viwjyLa_i8-JMI4Tw</recordid><startdate>20130709</startdate><enddate>20130709</enddate><creator>SAITOU, ATSUSHI</creator><creator>SUZUKI, SHIGERU</creator><creator>KIKUMOTO, SHIGEYUKI</creator><creator>YANAKA, MIKIRO</creator><creator>ONO, MASAHIRO</creator><creator>MATSUI, RYO</creator><creator>YAMAMOTO, MASASHI</creator><creator>SAWA, TOMOHIRO</creator><scope>EVB</scope></search><sort><creationdate>20130709</creationdate><title>A SUBSTITUTED-TRIALKYL AMINE COMPOUND WITH ANTI-VIRAL ACTIVITY BASED ON ANTAGONISM AGAINST A CHEMOKINE RECEPTOR CXCR4</title><author>SAITOU, ATSUSHI ; SUZUKI, SHIGERU ; KIKUMOTO, SHIGEYUKI ; YANAKA, MIKIRO ; ONO, MASAHIRO ; MATSUI, RYO ; YAMAMOTO, MASASHI ; SAWA, TOMOHIRO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2558600C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2013</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SAITOU, ATSUSHI</creatorcontrib><creatorcontrib>SUZUKI, SHIGERU</creatorcontrib><creatorcontrib>KIKUMOTO, SHIGEYUKI</creatorcontrib><creatorcontrib>YANAKA, MIKIRO</creatorcontrib><creatorcontrib>ONO, MASAHIRO</creatorcontrib><creatorcontrib>MATSUI, RYO</creatorcontrib><creatorcontrib>YAMAMOTO, MASASHI</creatorcontrib><creatorcontrib>SAWA, TOMOHIRO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SAITOU, ATSUSHI</au><au>SUZUKI, SHIGERU</au><au>KIKUMOTO, SHIGEYUKI</au><au>YANAKA, MIKIRO</au><au>ONO, MASAHIRO</au><au>MATSUI, RYO</au><au>YAMAMOTO, MASASHI</au><au>SAWA, TOMOHIRO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>A SUBSTITUTED-TRIALKYL AMINE COMPOUND WITH ANTI-VIRAL ACTIVITY BASED ON ANTAGONISM AGAINST A CHEMOKINE RECEPTOR CXCR4</title><date>2013-07-09</date><risdate>2013</risdate><abstract>Novel amine compounds which are represented by the following formula (1) and efficacious against diseases such as a viral infectious disease with HIV, rheumatism, and cancer metastasis; [Formula 1] (see formula 1) typically, A1 and A2 represent a hydrogen atom or a substitutable monocyclic or polycyclic heteroaromatic ring and W represents a substitutable benzene ring or any group represented by the following formula (10) or (11): [Formula 2] (see formula 10) [Formula 3] (see formula 11) where X represents O, CH2, C (=O) , NR11, or CHR35 and D represents a group represented by the following formula (6) : [Formula 4] (see formula 6) where Q represents a single bond, NR12, or a group represented by the formula (13) : [Formula 5] (see formula 13) and Y represents a group represented by the following formula (7): [Formula 6] (see formula 7) where Q represents a substitutable monocyclic or polycyclic aromatic ring; and B represents -NR25R26; and R1 to R26 in the above formulae represent a hydrogen atom, an alkyl group, an alkenyl group, or an alkynyl group.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | A SUBSTITUTED-TRIALKYL AMINE COMPOUND WITH ANTI-VIRAL ACTIVITY BASED ON ANTAGONISM AGAINST A CHEMOKINE RECEPTOR CXCR4 |
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