A SUBSTITUTED-TRIALKYL AMINE COMPOUND WITH ANTI-VIRAL ACTIVITY BASED ON ANTAGONISM AGAINST A CHEMOKINE RECEPTOR CXCR4

Novel amine compounds which are represented by the following formula (1) and efficacious against diseases such as a viral infectious disease with HIV, rheumatism, and cancer metastasis; [Formula 1] (see formula 1) typically, A1 and A2 represent a hydrogen atom or a substitutable monocyclic or polycyclic heteroaromatic ring and W represents a substitutable benzene ring or any group represented by the following formula (10) or (11): [Formula 2] (see formula 10) [Formula 3] (see formula 11) where X represents O, CH2, C (=O) , NR11, or CHR35 and D represents a group represented by the following formula (6) : [Formula 4] (see formula 6) where Q represents a single bond, NR12, or a group represented by the formula (13) : [Formula 5] (see formula 13) and Y represents a group represented by the following formula (7): [Formula 6] (see formula 7) where Q represents a substitutable monocyclic or polycyclic aromatic ring; and B represents -NR25R26; and R1 to R26 in the above formulae represent a hydrogen atom, an alkyl group, an alkenyl group, or an alkynyl group.