IMPROVED PROCESS FOR THE MANUFACTURE OF CITALOPRAM HYDROBROMIDE

The present invention describes an improved process for the preparation of extremely pure 1-(4'-Fluorophenyl)-1-(3-dimethylaminopropyl)-5- phthalanecarbonitrile and its bromide salt (citalopram hydrobromide), which is a well known antidepressant. Other aspect of the invention are isolation of c...

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Bibliographische Detailangaben
Hauptverfasser: BHARGAV, KRISHNAJI UPADHYE, JAWEED MUKARRAM, SIDDIQUI MOHAMMED, FAROOQUI, MOHAMMED ISMAIL, MISHRA, KRISHNA GOPALJI
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:The present invention describes an improved process for the preparation of extremely pure 1-(4'-Fluorophenyl)-1-(3-dimethylaminopropyl)-5- phthalanecarbonitrile and its bromide salt (citalopram hydrobromide), which is a well known antidepressant. Other aspect of the invention are isolation of crystalline (4-Bromo-2-hydroxymethyl)phenyl-(4-fluorophenyl)-3- (dimethylaminopropyl)methanol (Bromodiol) and conversion of desmethylcitalopram which is formed during the cyanide exchange reaction, to Citalopram by heating with a mixture of formaldhyde and formic acid in chloroform. The resulting citalopram is conventionally purified using extraction methodology.