DELIVERING GENETIC MATERIAL TO A STIMULATION SITE

Delivery of genetic material to a stimulation site causes transgene expressi on by tissue at the stimulation site. In some embodiments, the delivered geneti c material causes increased expression of proteins, such as connexins, gap junctions, and ion channels, to increase the conductivity of the tis...

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Hauptverfasser:	LASKE, TIMOTHY G, CASAS-BEJAR, JESUS, MARKOWITZ, H. TOBY, BLUM, JANELLE, EBERT, MICHAEL, CROSS, DAISY P, MONGEON, LUC R
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ELECTROTHERAPY ENZYMOLOGY HUMAN NECESSITIES HYGIENE MAGNETOTHERAPY MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS RADIATION THERAPY SPIRITS ULTRASOUND THERAPY VINEGAR WINE
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Beschreibung
Zusammenfassung:	Delivery of genetic material to a stimulation site causes transgene expressi on by tissue at the stimulation site. In some embodiments, the delivered geneti c material causes increased expression of proteins, such as connexins, gap junctions, and ion channels, to increase the conductivity of the tissue at t he stimulation site. In some embodiments, the delivered genetic material causes expression of a metalloproteinase, an anti-inflammatory agent, or an immunosuppressant agent. Genetic material is delivered to the stimulation si te via a stimulation lead. A stimulation lead for delivering genetic material t o a stimulation site includes a chamber that contains a polymeric matrix. The matrix absorbs the genetic material and elutes the genetic material to the stimulation site.