PROCESS FOR PREPARING POLYSACCHARIDE-PROTEIN CONJUGATE VACCINES

PROCESS FOR PREPARING POLYSACCHARIDE-PROTEIN CONJUGATE VACCINES

Methods for the manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group o n one reactant with an aldehyde group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency. Simplified purificat...

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Bibliographische Detailangaben
Hauptverfasser: FRASCH, CARL E, BASTOS, RENATA CHAGAS, LEE, CHE-HUNG ROBERT, JESSOUROUN, ELLEN, DA SILVEIRA, IVNA ALANA FREITAS BRASILEIRO
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Methods for the manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group o n one reactant with an aldehyde group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency. Simplified purification processes can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products .