NEW DIABETES TYPE 2 ANIMAL MODEL

A diabetes type 2 model laboratory animal is disclosed which comprises cells over-expressing GPR40 under the control of the Ipf1/Pdx1 promoter. Also disclosed is the use of the model animal for the identification of agonists or antagonists towards GPR40, useful for the development of pharmaceuticals...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	EDLUND, HELENA, RUBINS, NIR, WALKER, MICHAEL D, STENEBERG, PAR
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPIRITS TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	A diabetes type 2 model laboratory animal is disclosed which comprises cells over-expressing GPR40 under the control of the Ipf1/Pdx1 promoter. Also disclosed is the use of the model animal for the identification of agonists or antagonists towards GPR40, useful for the development of pharmaceuticals towards treatment of the disease.