METABOLITE OF XANTHINE PHOSPHODIESTERASE 5 INHIBITOR AND DERIVATIVES THEREOF USEFUL FOR TREATMENT OF ERECTILE DYSFUNCTION

The present invention is directed to a metabolite of a xanthine Phosphodiesterase type 5 inhibitor having the following structure derivative s, and formulations thereof, and processes for preparing the same. Further disclosed are methods of treating a physiological disorder, symptom or disea se in a...

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Hauptverfasser: ZBAIDA, SHMUEL, CHOWDHURY, SWAPAN K, TONG, WEI, WIRTH, MARK A, STAMFORD, ANDREW, BOYLE, CRAIG D, ALTON, KEVIN B, PATRICK, JAMES E, GHOSAL, ANIMA
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Sprache:eng ; fre
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Zusammenfassung:The present invention is directed to a metabolite of a xanthine Phosphodiesterase type 5 inhibitor having the following structure derivative s, and formulations thereof, and processes for preparing the same. Further disclosed are methods of treating a physiological disorder, symptom or disea se in a patient, comprising administering to the patient an effective amount of the above compound, wherein the physiological disorder, symptom or disease i s a urogenital, cardiovascular, cerebrovascular or peripheral vascular disorde r, angina pectoris, hypertension, restenosis post angioplasty, endarterectomy, stent introduction, cerebral stroke, a respiratory tract disorder such as an allergic condition associated with atopy, pulmonary hypertension, an ischemi c heart disorder, impaired glucose tolerance, diabetes and its related complication, insulin resistance syndrome, hyperglycemia, polycystic ovarian syndrome, a glomerular disorder, renal insufficiency, nephritis, a tubular interstitial disorder, an autoimmune disorder, glaucoma, intestinal motility , cachexia or cancer.