A METHOD FOR THE PREPARATION OF ENANTIOMERICALLY PURE MIRTAZAPINE

A METHOD FOR THE PREPARATION OF ENANTIOMERICALLY PURE MIRTAZAPINE

The invention provides a method for the preparation of enantiomerically pure mirtazapine, said method comprising a step of ring closure of a compound of formula (II) wherein X is a leaving group, said step comprising treatment with an acid, whereby mirlazapine with enantiomeric excess is formed by t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: VAN DE VEN, ADRIANUS ANTONIUS MARTINUS, KEMPERMAN, GERARDUS JOHANNES, WIERINGA, JOHANNES HUBERTUS
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention provides a method for the preparation of enantiomerically pure mirtazapine, said method comprising a step of ring closure of a compound of formula (II) wherein X is a leaving group, said step comprising treatment with an acid, whereby mirlazapine with enantiomeric excess is formed by the ring closure of the compound of formula (II) with enantiomeric excess by treatment with a suitable acid in the absence of a solvent or a suitable combination of an acid and an organic solvent.