ACYLATED AMINO ACID AMIDYL PYRAZOLES AND RELATED COMPOUNDS

This invention is directed to acylated amino acid amidyl pyrazoles and related compounds of Formula (I). The invention is also directed to a pharmaceutical formation comprising such compound or in a pharmaceutically acceptable salt form thereof. The invention is further directed to a method for inhi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	PLEISS, MICHAEL A, TUCKER, JOHN, LATIMER, LEE H, DRESSEN, DARREN, GUINN, ASHLEY C, JENKINS, SCOTT A, SEALY, JENNIFER, TUNG, JAY S, GAROFALO, ALBERT, WU, JING, WONE, DAVID W. G
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This invention is directed to acylated amino acid amidyl pyrazoles and related compounds of Formula (I). The invention is also directed to a pharmaceutical formation comprising such compound or in a pharmaceutically acceptable salt form thereof. The invention is further directed to a method for inhibiting .beta.-amyloid peptide release and/or synthesis, a method for inhibiting .gamma.--secretase activity, and a method for treating neurological disorders associated with .beta.-amyloid peptide production. The method comprises administering to a host a pharmaceutical formulation comprising an effective amount of a compound of Formula (I). The compounds of Formula (I) are useful in the prevention and treatment of Alzheimer's disease. (see formula I)