PREPARATION OF SUBSTITUTED QUINOXALINES FROM THE DIANLINE WITH 2,3-DIHYDROXY-1,4-DIOXANE

PREPARATION OF SUBSTITUTED QUINOXALINES FROM THE DIANLINE WITH 2,3-DIHYDROXY-1,4-DIOXANE

The present invention relates to a new process for the preparation of substituted quinoxalines (I) by cyclization of the corresponding dianiline with 2,3 dihydroxy-1,4-dioxane. In a preferred embodiment, the invention provides a process for the preparation of compounds having the formula III wherein...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: RAINVILLE, JOSEPH PHILIP, TABER, GERALDINE PATRICIA
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to a new process for the preparation of substituted quinoxalines (I) by cyclization of the corresponding dianiline with 2,3 dihydroxy-1,4-dioxane. In a preferred embodiment, the invention provides a process for the preparation of compounds having the formula III wherein Q is a nitrogen protecting group. Compounds of formula III and their derivatives are precursors to certain aryl fused azapolycyclic compounds whi ch exhibit activity as agents for the treatment of neurological and psychologic al disorders.