CYCLIC QUATERNARY AMINO DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS

Compounds of formula (1) wherein,m,n,R1,R2,Ra,ALK3, E and Y are as defined i n the claims, being potent and selective inhibitors of chemokine binding to th e CXCR3 receptor, are accordingly of use in the treatment and/or prevention of conditions involving inappropriate T-cell trafficking, including...

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Hauptverfasser:	MEISSNER, JOHANNES WILHELM GEORG, OWEN, DAVID ALAN, WATSON, ROBERT JOHN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	MEISSNER, JOHANNES WILHELM GEORG OWEN, DAVID ALAN WATSON, ROBERT JOHN
description	Compounds of formula (1) wherein,m,n,R1,R2,Ra,ALK3, E and Y are as defined i n the claims, being potent and selective inhibitors of chemokine binding to th e CXCR3 receptor, are accordingly of use in the treatment and/or prevention of conditions involving inappropriate T-cell trafficking, including inflammator y, autoimmune and immurforegulatory disorders such as rheumatoid arthritis.
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	CYCLIC QUATERNARY AMINO DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS
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