CYCLIC QUATERNARY AMINO DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS

CYCLIC QUATERNARY AMINO DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS

Compounds of formula (1) wherein,m,n,R1,R2,Ra,ALK3, E and Y are as defined i n the claims, being potent and selective inhibitors of chemokine binding to th e CXCR3 receptor, are accordingly of use in the treatment and/or prevention of conditions involving inappropriate T-cell trafficking, including...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MEISSNER, JOHANNES WILHELM GEORG, OWEN, DAVID ALAN, WATSON, ROBERT JOHN
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Compounds of formula (1) wherein,m,n,R1,R2,Ra,ALK3, E and Y are as defined i n the claims, being potent and selective inhibitors of chemokine binding to th e CXCR3 receptor, are accordingly of use in the treatment and/or prevention of conditions involving inappropriate T-cell trafficking, including inflammator y, autoimmune and immurforegulatory disorders such as rheumatoid arthritis.