PURIFICATION OF BIOLOGICALLY-PRODUCED 1,3-PROPANEDIOL

A process for purifying 1,3-propanediol from the fermentation broth of a cultured E. coli that has been bioengineered to synthesize 1,3-propanediol from sugar is provided. The basic process entails filtration, ion exchange and distillation of the fermentation broth product stream, preferably includi...

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Hauptverfasser:	FITZGIBBON, PATRICK, LEHNHARDT, WILLIAM F, TROTTER, ROBERT E, DRAVIS, BRYAN C, AMES, TYLER T, LUYBEN, MICHAEL L, SEAPAN, MAYIS, GADDY, JAMES M, YU, EUGENE K, LIEVENSE, JEFFERSON C, ALSOP, ALBERT W, DISNEY, JAMES M, GALLAGHER, F. GLENN, WENNDT, GREGORY M, CHU, LUIS ALBERTO, ADKESSON, DENNIS MICHAEL
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL SEPARATION SPIRITS TRANSPORTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	A process for purifying 1,3-propanediol from the fermentation broth of a cultured E. coli that has been bioengineered to synthesize 1,3-propanediol from sugar is provided. The basic process entails filtration, ion exchange and distillation of the fermentation broth product stream, preferably including chemical reduction of the product during the distillation procedure. Also provided are highly purified compositions of 1,3-propanediol. La présente invention concerne un procédé permettant de purifier du 1,3-propanediol issu du bouillon de fermentation d'une culture de E. coli qui a été traité par génie biologique pour synthétiser le 1,3-propanediol à partir du sucre. Le procédé de base fait intervenir une filtration, un échange d'ions et une distillation du diluat du bouillon de fermentation, de préférence avec réduction chimique du produit pendant la distillation. L'invention concerne également des compositions hautement purifiées à base de 1,3-propanediol.