SUBSTITUTED ISOCHROMAN COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS, CANCER AND OTHER DISEASES

SUBSTITUTED ISOCHROMAN COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS, CANCER AND OTHER DISEASES

The invention relates to novel heterocyclic compounds having the structure illustrated by Formula (1) wherein the Ar1 radicals are substituted isochrom an radicals, the Ar2 radicals are aryl or heteroaryl radicals; and HAr is a 2,4 - thiazolidinedione, 2-thioxo-thiazolidine-4-one, 2,4-imidazolidined...

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Bibliographische Detailangaben
Hauptverfasser: ZAPF, JAMES W, GIACHINO, ANDREA FANJUL, TACHDJIAN, CATHERINE, CHEN, QING, JAKUBOWICZ-JAILLARDON, KARINE, PFAHL, MAGNUS, AL-SHAMMA, HUSSIEN A, GUO, JIANHUA, BOUDJELAL, MOHAMED
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:The invention relates to novel heterocyclic compounds having the structure illustrated by Formula (1) wherein the Ar1 radicals are substituted isochrom an radicals, the Ar2 radicals are aryl or heteroaryl radicals; and HAr is a 2,4 - thiazolidinedione, 2-thioxo-thiazolidine-4-one, 2,4-imidazolidinedione or 2- thioxo-imidazolidine-4-one radical. The compounds of Formula (1) can have biological activity for advantageously regulating carbohydrate metabolism, including serum glucose level, and lipid metabolism, and can be useful for t he treatment of hyperlipidernia and/or hypercholesterolemia, and Type 11 diabetes. The compounds of Formula (1) can also have utility in the treatmen t of diseases of uncontrolled proliferation, including cancer.