PROCESSES FOR THE PREPARATION OF N-((((PYRIDINYLOXY)-PHENYLAMINO) QUINAZOLINYL)-ALLYL) ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS WELL AS INTERMEDIATES OF SUCH PROCESSES AND PROCESSES FOR THE PREPARATION OF SUCH INTERMEDIATES

The invention relates to processes for preparing compounds of the formula (1 ) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R3, R4, R6 R11, R13 R14 R15, R16, R17, k, I, and m are as define d herein. The present invention also relates to intermediates represent...

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Hauptverfasser: RIPIN, DAVID HAROLD BROWN, VETELINO, MICHAEL GIRARD, WEI, LULIN
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:The invention relates to processes for preparing compounds of the formula (1 ) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R3, R4, R6 R11, R13 R14 R15, R16, R17, k, I, and m are as define d herein. The present invention also relates to intermediates represented by t he formula (3a) wherin R4, and R5 are independently selected from hydrogen and C1- C6alkyl; each R13, R14, R15 and R16 is independently selected from hydrogen, C1-C6alkyl and CH2OH, R17 and R18 are independently C1-C6 alkyl, and k and I are independently an integer from 1 to 3, as well as to a process for preparing these intermediates.