ANTIBODIES TO IGF-I RECEPTOR FOR THE TREATMENT OF CANCERS

Antibodies specific for Insulin-like growth factor I receptor (IGF-R) are provided. The antibodies and fragments thereof may block binding of IGF-I to IGF-IR. Antagonist antibodies can be employed to block binding of IGF-I to IFGF-IR or substantially inhibit IGF-IR activation. The IGF-IR antibodies...

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Bibliographische Detailangaben
Hauptverfasser:	RUNNELS, HERBERT A, MORTON, PHILIP A, ARBUCKLE, J. ALAN, BAILEY, KAREN S, NICASTRO, PETER J
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Antibodies specific for Insulin-like growth factor I receptor (IGF-R) are provided. The antibodies and fragments thereof may block binding of IGF-I to IGF-IR. Antagonist antibodies can be employed to block binding of IGF-I to IFGF-IR or substantially inhibit IGF-IR activation. The IGF-IR antibodies ma y be included in pharmaceutical compositions, articles of manufacture, or kits . Methods of treating cancer using the IGF-IR antibodies are also provided.