PREPARATION OF QUINAPRIL HYDROCHLORIDE

PREPARATION OF QUINAPRIL HYDROCHLORIDE

Methods and materials for preparing quinapril, its pharmaceutically acceptab le salts, including quinapril hydrochloride, are disclosed. The method includes reacting (2S,4S)-2-(4-methyl-2,5-dioxo-oxazolidin-3-yl)-4-phenyl-butyric aci d ethyl ester with (3S)-1,2,3,4-tetrahydro-isoquinoline-3-carboxyl...

Ausführliche Beschreibung

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Bibliographische Detailangaben
1. Verfasser: JENNINGS, SANDRA MARIE
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Methods and materials for preparing quinapril, its pharmaceutically acceptab le salts, including quinapril hydrochloride, are disclosed. The method includes reacting (2S,4S)-2-(4-methyl-2,5-dioxo-oxazolidin-3-yl)-4-phenyl-butyric aci d ethyl ester with (3S)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid tert - butyl ester toyield quinapril tert-butyl ester, which is subsequently reactedwith an acid to yield quinapril or an acid addition salt of quinapril .