BENZOXAZIN-3-ONES AND DERIVATIVES THEREOF AS INHIBITORS OF PI3K

The present invention provides compounds of Formula (I) wherein W, Q, E, D, R6, R7, R8, Y, K, R9, R1O, R12, G, and the double bond denoted "*" have any of the values defined therefore in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the trea...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	PARA, KIMBERLY SUZANNE, BARVIAN, NICOLE CHANTEL, VISNICK, MELEAN, PATT, WILLIAM CHESTER, KOLZ, CHRISTINE NYLUND
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides compounds of Formula (I) wherein W, Q, E, D, R6, R7, R8, Y, K, R9, R1O, R12, G, and the double bond denoted "*" have any of the values defined therefore in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (I). The compounds are inhibitor s of phosphoinsitide-3-kinase (P13K).