ANTIBODIES DIRECTED TO TUMOR NECROSIS FACTOR AND USES THEREOF

Antibodies directed to the antigen TNFa and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFa. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	SENALDI, GIORGIO, MANCHULENKO, KATHY, PIGOTT, CRAIG, BABCOOK, JOHN S, KANG, JASPAL S, LEE, ROZANNE, RATHANASWAMI, PALANISWAMI, FAGGIONI, RAFFAELLA, GREEN, LARRY, FOORD, ORIT, FENG, XIAO, SU, QIAOJUAN JANE, HAAK-FRENDSCHO, MARY, LIANG, MEINA L, KLAKAMP, SCOTT
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Antibodies directed to the antigen TNFa and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFa. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies. Cette invention concerne des anticorps agissant sur l'antigène TNF et leurs utilisations. L'invention concerne en particulier : des anticorps monoclonaux entièrement humains agissant sur l'antigène TNFa; des séquences de nucléotides codant pour, et des séquences d'acides aminés comprenant, des molécules d'immunoglobuline à chaînes lourde et légère, en particulier des séquences correspondant aux chaînes contiguës lourdes et légères occupant les régions structurales et/ou les régions hypervariables (CDR), specifiquement de FR1 à FR4 ou de CDR1 à CDR3; des hybridomes ou autres lignées cellulaires exprimant de telles molécules d'immunoglobuline et d'anticorps monoclonaux.