ASSAY

To date phylogeny has been used to compare entire families of proteins based on their nucleotide or amino-acid sequence. The present invention is directed to a novel analytical platform allowing the systematic comparison of families of protei ns based on their biochemical properties utilizing high t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	EUN-HYE, LEE, JENNA, SARAH, CARUSO, MARIE-ELAINE, CHEVET, ERIC
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To date phylogeny has been used to compare entire families of proteins based on their nucleotide or amino-acid sequence. The present invention is directed to a novel analytical platform allowing the systematic comparison of families of protei ns based on their biochemical properties utilizing high throughput assays. Integration a nd hierarchical clustering of the results for the Rho subfamily of GTPases revealed unexpected features of the small Rho GTPases when compared to amino-acid sequence-based trees. A novel phylo-biochemical classification of the Ras superfamily of GTPases is proposed.