SUBSTITUTED PYRIDINES VIA BORONIC ACID COUPLING

SUBSTITUTED PYRIDINES VIA BORONIC ACID COUPLING

The invention relates to a convergent process for preparing a compound of th e formula (V), wherein R1 is attached at the 2 or 3 position of the benzene ring, R2 is attached at the 5 or 6 position and R1, R2 and G are as defined herein, in which an aryl boronic acid is coupled with an amine protecte...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: NOWAKOWSKI, JOLANTA, CARON, STEPHANE
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to a convergent process for preparing a compound of th e formula (V), wherein R1 is attached at the 2 or 3 position of the benzene ring, R2 is attached at the 5 or 6 position and R1, R2 and G are as defined herein, in which an aryl boronic acid is coupled with an amine protected hal o- substituted-2-aminopyridine using a palladium coupling agent. Compounds of formula (V) are useful as nitric oxide synthase (NOS) inhibitors in a mammal .