THERAPEUTIC COMBINATIONS FOR THE TREATMENT OF HORMONE DEFICIENCIES

The present invention relates to methods of treating, preventing, or reducin g the risk of developing a male or female menopause disorder or symptom in a mammal by administering to the mammal a s ex hormone binding globulin synthesis inhibiting agent and one or more steroids, including, for example, an androgen or an estrogen; to combinations for treating, preventing or reducing the risk of developing a male or female menopause disorder or sympt om in a mammal, and to compositions for treating, preventing, or reducing the risk of developing a male or female menopause disorder or symptom in a mammal, where the composition comprises a sex binding globulin synthesis inhibiting agent and one or more steroids, including, for example, an androgen or an estrogen. In addition, the methods, combinations and compositions may be use d in conjunction with other pharmaceutical agents aimed at improving sexual performance or impotence, increasing libido, or treating erectile dysfunction, such as VIAGRA.RTM., to enhance their effectiveness.