METHODS FOR THE PREPARATION, ISOLATION AND PURIFICATION OF EPOTHILONE B, AND X-RAY CRYSTAL STRUCTURES OF EPOTHILONE B

The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification. L'invention concer...

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Hauptverfasser:	CHIANG, SHU-JEN, COMEZOGLU, FAHRI T, HOU, DAVID, MINTZMYER, LES, HARGRO, IVAN, MASCARI, MARK, TULLY, THOMAS P, STANKAVAGE, ROBERT, EAGAN, BRUCE, HOU, HSING, GU, DENNIS, MCCONLOGUE, CARY W, BENIGNI, DANIEL, STEIN, GREGORY, DAVIS, BRIAN L, GALVIN, GABRIEL
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification. L'invention concerne des procédés améliorés de production, d'isolation et de purification d'épothilone B. Ces procédés comprennent, par exemple, un processus de fermentation pour la production d'épothilone B, d'isolation via l'adsorption sur une résine et de purification subséquente.