FIBRINOGEN PURIFICATION

The present invention relates to a process for purifying fibrinogen, which comprises one or more process steps in which one or more contaminating proteins are depleted by negative chromatography and/or negative adsorption using cation exchanger, hydrophobic gel and/or dye gel. In addition, the inven...

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Bibliographische Detailangaben
Hauptverfasser:	LIEBING, UWE, FEUSSNER, ANNETTE, SCHULTE, STEFAN, LEMMER, JOERG, METZNER, HUBERT, GAWANTKA, VOLKER
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a process for purifying fibrinogen, which comprises one or more process steps in which one or more contaminating proteins are depleted by negative chromatography and/or negative adsorption using cation exchanger, hydrophobic gel and/or dye gel. In addition, the invention relates to the fibrinogen which is obtained by the process of the invention and which is notable for improved stability, and to the production and use of pharmaceutical preparations comprising this fibrinogen. La présente invention porte sur un procédé de purification du fibrinogène, qui comprend une ou plusieurs étapes de procédé dans lesquelles une ou plusieurs protéines contaminantes sont appauvries par chromatographie négative ou adsorption négative au moyen dun échangeur de cations, dun gel hydrophobe ou dun gel colorant. De plus, linvention porte sur le fibrinogène qui est obtenu au moyen du procédé de linvention et qui est notable pour sa stabilité améliorée, et sur la production et lutilisation de préparations pharmaceutiques renfermant ce fibrinogène.