7-PHENYLPYRAZOLOPYRIDINE COMPOUNDS

7-PHENYLPYRAZOLOPYRIDINE COMPOUNDS

A compound represented by the formula: (see figure I) [wherein R1 is methoxy, methylthio, ethyl, etc.; R5 and R6 are each independently cyclopropylmethyl, (4--tetrahydropyranyl) methyl, etc.; and two of R40, R41 and R42 are C1-6 alkoxy while the remaining one is methoxymethyl, etc.], a salt thereof,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: HOSHINO, YORIHISA, KIKUCHI, KOICHI, SHIN, KOGYOKU, HIBI, SHIGEKI, FUJISAWA, MASAE, INO, MITSUHIRO, TAKAHASHI, YOSHINORI, SHIBATA, HISASHI
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:A compound represented by the formula: (see figure I) [wherein R1 is methoxy, methylthio, ethyl, etc.; R5 and R6 are each independently cyclopropylmethyl, (4--tetrahydropyranyl) methyl, etc.; and two of R40, R41 and R42 are C1-6 alkoxy while the remaining one is methoxymethyl, etc.], a salt thereof, or a hydrate of the foregoing. This compound has excellent antagonism against corticotropin-releasing factor receptor. L'invention concerne un composé représenté par la formule générale (I), son sel ou des hydrates correspondants. Dans cette formule, R?1¿ représente méthoxy, méthylthio, éthyle, etc., R?5¿ et R?6¿ représentent chacun indépendamment cyclopropylméthyle, (4-tétrahydropyranyl)méthyle, etc., et deux de R?40¿, R?41¿ et R?42¿ sont alcoxy C¿1-6?, le reste se composant de méthoxyméthyle, etc. Le composé susmentionné présente un excellent antagonisme vis-à-vis d'un récepteur du facteur de libération de la corticotropine.