MCAM INHIBITORS

The present invention relates to polypeptides inhibiting the function of MCA M in naturally occurring tumor cells and their use, and the use of other molecules inhibiting MCAM function, for the treatment of cancers, particular ly for reducing the invasiveness, proliferation, adhesion and/or the meta...

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Bibliographische Detailangaben
Hauptverfasser:	AHRENS, BIANCA, ZEHETMEIER, CAROLIN, UNGER, CHRISTINE MARGARETE, BESTE, GERALD, TORELLA, CLAUDIA, NIEWOHNER, JENS
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to polypeptides inhibiting the function of MCA M in naturally occurring tumor cells and their use, and the use of other molecules inhibiting MCAM function, for the treatment of cancers, particular ly for reducing the invasiveness, proliferation, adhesion and/or the metastatic potential of specific cancer cells. Furthermore, a method is provided that allows determining whether a naturally occurring tumor cell depends on functional MCAM for its invasiveness, adhesiveness, proliferation and/or its metastatic potential. Finally, a method is provided that allows identifying an antibody or an antibody fragment capable of inhibiting invasiveness, proliferation or adhesiveness of tumor cells.