HUMAN ADAM-10 INHIBITORS

The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibitors) in biological processes. The present invention also comprises pharmaceutical compositions com...

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Bibliographische Detailangaben
Hauptverfasser:	MAMO, SHUMEYE, LEW-TSUHAKO, AMY, LE, DONNA TRA, MAC, MORRISON B, XU, WEI, WEN, ZHAOYANG, BANNEN, LYNNE CANNE, KIM, MOON HWAN, JAMMALAMADAKA, VASU, CO, ERICK W, KHOURY, RICHARD GEORGE, NUSS, JOHN M
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibitors) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and disease related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The following structural formula may best represent characteristics of the present invention: (see above formula)