PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED-3-QUINOLINE AND3-QUINOL-4-ONE CARBONITRILES

PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED-3-QUINOLINE AND3-QUINOL-4-ONE CARBONITRILES

There is provided a process for the preparation of 7-substituted-3- quinolinecarbonitriles and intermediates useful in a process to prepare 7- substituted-3-quinolinecarbonitriles and pharmaceutically acceptable salts i s described. Where 7-fluoro-4-oxo-1,4-dihydro-3-quinolinecarbonitrile is convert...

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Bibliographische Detailangaben
Hauptverfasser: BOSCHELLI, DIANE HARRIS, BERGER, DAN MAARTEN, JOHNSON, STEVEN LAWRENCE, WANG, YANONG DANIEL
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:There is provided a process for the preparation of 7-substituted-3- quinolinecarbonitriles and intermediates useful in a process to prepare 7- substituted-3-quinolinecarbonitriles and pharmaceutically acceptable salts i s described. Where 7-fluoro-4-oxo-1,4-dihydro-3-quinolinecarbonitrile is converted in three steps to 7-substituted-3-quinolinecarbonitriles which inhibit the action of certain protein kinases and are useful in the treatmen t of cancer.