PROCESS FOR PREPARING OPTICALLY ACTIVE BETA-AMINOCARBOXYLIC ACIDS FROM RACEMIC N-ACYLATED BETA-AMINOCARBOXYLIC ACIDS

PROCESS FOR PREPARING OPTICALLY ACTIVE BETA-AMINOCARBOXYLIC ACIDS FROM RACEMIC N-ACYLATED BETA-AMINOCARBOXYLIC ACIDS

A process is described for preparing optically active .beta.-aminocarboxylic acids from racemic N-acylated .beta.-aminocarboxylic acids by enantioselecti ve hydrolysis of the N-acylated .beta.-aminocarboxylic acid in the presence of a hydrolase by way of biocatalyst, wherein the N-acyl substituent o...

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Bibliographische Detailangaben
Hauptverfasser: WERNER, HELGE, DRAUZ, KARLHEINZ, GROEGER, HARALD, TRAUTHWEIN, HARALD, BUCHHOLZ, STEFAN, SACHERER, CHRISTIANE
Format: Patent
Sprache:eng ; fre
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
PROCESSES USING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Zusammenfassung:A process is described for preparing optically active .beta.-aminocarboxylic acids from racemic N-acylated .beta.-aminocarboxylic acids by enantioselecti ve hydrolysis of the N-acylated .beta.-aminocarboxylic acid in the presence of a hydrolase by way of biocatalyst, wherein the N-acyl substituent of the N- acylated .beta.-aminocarboxylic acid (I) exhibits Structure I in which R1, R 2 are each selected, independently of one another, from H, halogen, alkyl residues, OH, alkoxy residues and aryloxy residues; R3 is selected from halogen, alkoxy residues and aryloxy residues; (II) Structure IIA or IIB or the structure of the corresponding salts or (III) Structure III or the structure of the corresponding salt.