COMPOSITIONS AND METHODS FOR INHIBITION OF PHOSPHOLIPASE A2 MEDIATED INFLAMMATION

Specific, highly potent 2-oxo-amide based inhibitors of phospholipase A2 (PLA2) activity are provided. A role for PLA2 activity in spinally mediated inflammatory processes is established, and a method for treating hyperalgesia and other inflammatory conditions associated with PLA2 activity is provid...

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Hauptverfasser: LUCAS, KARIN KILLERMANN, KOKOTOS, GEORGE, YAKSH, TONY, CONSTANTINOU-KOKOTOU, VIOLETTA, DENNIS, EDWARD, SIX, DAVID A, SVENSSON, CAMILLA
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:Specific, highly potent 2-oxo-amide based inhibitors of phospholipase A2 (PLA2) activity are provided. A role for PLA2 activity in spinally mediated inflammatory processes is established, and a method for treating hyperalgesia and other inflammatory conditions associated with PLA2 activity is provided.