MUTANT ACTINOSYNNEMA PRETIOSUM STRAIN WITH INCREASED MAYTANSINOID PRODUCTION

A microorganism that is a mutant bacterial strain of the species Actinosynnema pretiosum, designated PF4-4, (ATCC PTA-3921), being capable of producing maytansinoid ansamitocins such as ansamitocin P-3 in improved yield compared to previous known strains, and capable of growth under varied culture c...

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Bibliographische Detailangaben
Hauptverfasser:	CHUNG, JOHNSON, BYNG, GRAHAM S
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A microorganism that is a mutant bacterial strain of the species Actinosynnema pretiosum, designated PF4-4, (ATCC PTA-3921), being capable of producing maytansinoid ansamitocins such as ansamitocin P-3 in improved yield compared to previous known strains, and capable of growth under varied culture conditions, and methods of producing maytansinoid ansamitocins by culturing PF4-4 in a suitable growth medium. L'invention concerne un micro-organisme se présentant sous la forme d'une souche bactérienne mutante de l'espèce Actinosynnema pretiosum, désignée par PF4-4 (ATCC PTA-3921), pouvant produire des ansamiticines maytansinoïdes telles que l'ansamitocine P-3 à un meilleur rendement que des souches déjà connues, et pouvant se développer sous différentes conditions de culture. L'invention se rapporte en outre à des procédés de production d'ansamitocines maytansinoïdes, par culture de PF4-4 dans un milieu de croissance approprié.