ZONIPORIDE MESYLATE PHARMACEUTICAL COMPOSITIONS AND PROCESSES FOR IMPROVING SOLUBILITY OF ZONIPORIDE

A pharmaceutical composition comprising Zoniporide (N-(5-cyclopropyl-l- quinolin-5yl-lh-pyrazole-4-carbonyl)-guanidine) or its mesylate salt in the presence of an aqueous diluent in the ph range of 2 to 3.5.The composition is a sodium hydrogen exchange-1 (NHE-1)inhibitor for the prevention of,inter...

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Bibliographische Detailangaben
1. Verfasser:	ARENSON, DANIEL RAY
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A pharmaceutical composition comprising Zoniporide (N-(5-cyclopropyl-l- quinolin-5yl-lh-pyrazole-4-carbonyl)-guanidine) or its mesylate salt in the presence of an aqueous diluent in the ph range of 2 to 3.5.The composition is a sodium hydrogen exchange-1 (NHE-1)inhibitor for the prevention of,inter alia,perioperative myocardial ischemic injury in mammals.Moreover the application relates to a process for increasing the solubility of Zoniporide employing methanesulfonic acide