ENTRAPPED BINDING PROTEINS AS BIOSENSORS

ENTRAPPED BINDING PROTEINS AS BIOSENSORS

The invention is directed to entrapped binding proteins, mutated binding proteins containing reporter groups, compositions of mutated binding proteins containing reporter groups in analyte permeable matrices, and their use as analyte biosensors both in-vitro and in vivo. The binding proteins are cov...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PITNER, J., BRUCE, KNORS, CHRISTOPHER J, ALARCON, JAVIER
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Beschreibung
Zusammenfassung:The invention is directed to entrapped binding proteins, mutated binding proteins containing reporter groups, compositions of mutated binding proteins containing reporter groups in analyte permeable matrices, and their use as analyte biosensors both in-vitro and in vivo. The binding proteins are covalently bound to a fluorescein dye so that the concentration of an analyte (e.g., glucose) in a given sample is proportional to the fluorescence signal on a scale.